Using XACDURO
Dosing and administration
Quick reference
Dosing for patients 18 years of age and older
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| XACDURO Dosing | Estimated CLcr* (mL/min) | Frequency |
|---|---|---|
| sulbactam 1 g and durlobactam 1 g | Greater than or equal to 130 | Every 4 hours |
| 45 to 129 | Every 6 hours | |
| 30 to 44 | Every 8 hours | |
| 15 to 29 | Every 12 hours | |
| less than 15† | For patients initiating XACDURO: Every 12 hours for the first 3 doses (0, 12, and 24 hours), followed by every 24 hours after the third dose† For patients currently receiving XACDURO whose CLcr declines to less than 15 mL/min: Every 24 hours |
Administer all doses of XACDURO by intravenous infusion over 3 hours.
The recommended duration of treatment with XACDURO is 7 to 14 days.
The duration of therapy should be guided by the patient's clinical status.
CLcr=creatinine clearance estimated by Cockcroft-Gault equation.
For patients on hemodialysis, the dose should be administered after the dialysis session has ended.
Preparation steps
1
Reconstitute the sulbactam 1 g single-dose vial with 5 mL of Sterile Water for Injection and gently shake to dissolve. Each reconstituted vial contains 1 g of sulbactam per 5 mL of clear, colorless to slightly yellow solution.*
2
Reconstitute each of the 2 durlobactam 0.5 g single-dose vials with 2.5 mL of Sterile Water for Injection and gently shake to dissolve. Each reconstituted vial contains 0.5 g of durlobactam per 2.5 mL of clear, light yellow to orange solution.*
3
To prepare the required dose, withdraw 5 mL of reconstituted sulbactam and 5 mL (2.5 mL from each vial) of reconstituted durlobactam. Add the withdrawn volume of both sulbactam and durlobactam to a 100 mL infusion bag of 0.9% Sodium Chloride for Injection, USP. Discard unused portion.
The reconstituted solution is not for direct injection and must be diluted before intravenous infusion. Dilution must occur within 1 hour of reconstitution
Inspect visually for particulate matter and discoloration prior to administration.
The prepared XACDURO solution should appear as a clear, light yellow to orange solution, free of particulates. If the XACDURO solution is cloudy or contains particulates, do not administer.
How to administer and store
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